• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The device (1) for removing air from an anatomical cavity (6) in a surgical operation, comprises a flexible catheter (2) with one or more lumens (10, 11) having a proximal end (3) and a distal end (4), each lumen (10, 11) presenting one or more holes (12, 13) at an end portion (9) of the catheter (2) comprising the distal end (4), means (5 being also provided) ) for the suction of air from the anatomical cavity, means (7) for blowing into the anatomical cavity of an air-replacing gas having a higher air density, and means (8) for raising said terminal portion (9) of the catheter ( 2) because of its placement at the top of the anatomical cavity, the insufflation means (7) and said suction means (5) being connected to the proximal end (3) of the catheter (2).
    公开号:CH711858A2
    申请号:CH01792/15
    申请日:2015-12-09
    公开日:2017-06-15
    发明作者:Demertzis Stefanos；Vandenberghe Stijn
    申请人:Fond Cardiocentro Ticino (Fcct)；
    IPC主号:
    专利说明:

    Description [0001] The present invention relates to a device for removing air from an anatomical cavity in a surgical intervention.
    [0002] The preferred but non-exclusive field of application of the invention is cardiac surgery.
    [0003] Air is a critical issue in surgery and not only in the heart.
    [0004] Especially when using a heart-lung machine and an external circuit must be connected to the patient's circulation, air bubbles can enter the patient.
    [0005] Even when anatomical structures filled with blood are surgically opened, air can enter the patient's bloodstream.
    [0006] Furthermore, the use of catheters and other hollow instruments can favor the introduction of air into the patient's bloodstream.
    [0007] The air does not dissolve in the blood but creates bubbles of various diameters that can obstruct the blood vessels and thus represent a threat to the life of the patient if they are able to reach and block cerebral and coronary blood vessels. This can in fact lead to the onset of a coronary or cerebral infarction.
    [0008] Air bubbles of smaller diameter, although potentially non-lethal, can decrease the heart's pumping efficiency and cognitive functions.
    [0009] Avoiding the entry of air into the bloodstream is therefore a priority in surgery.
    [0010] When an organ is surgically opened and comes into contact with the atmosphere, it is generally isolated from the patient's bloodstream by clamping the blood vessels. At the end of the intervention it is imperative to ensure the complete elimination of the air in the repaired organ before removing the clamping to reinsert the repaired organ into the bloodstream.
    [0011] However, it is not possible to clamp all blood vessels in all surgical procedures so that air can enter the bloodstream during surgery.
    [0012] The state of the art teaches us to blow CO2 gas to avoid the accumulation of air in the operating field.
    [0013] The C02 gas is sprayed by a nozzle placed above the patient and being heavier than the air it descends towards the operating field and replaces the air.
    [0014] The C02 gas dissolves in the blood and it is highly unlikely that bubbles will form which could endanger the patient's safety. C02 appears naturally in the blood as a result of metabolism and is expelled through breathing in the lungs.
    [0015] The state of the art in the field of cardiac surgery also teaches to remove air from the ventricle at the end of the surgery by insufflating C02 in the thoracic cavity and tilting and / or rotating the operating table, while air is sucked from the aorta ascending and / or through a suction catheter in the left atrium or ventricle.
    [0016] However, C02 administered in the traditional way (insufflation in the operating field) is not always able to reach the most distant anatomical cavities in the heart which are transformed into air traps.
    [0017] When the heart resumes beating and introduces blood into the ascending aorta the trapped air reaches the coronary arteries while the active suction in the ascending aorta is in a more distal position and consequently has a limited effectiveness in the prevention of a coronary embolism.
    [0018] The technical task proposed by the present invention is, therefore, to provide a device for removing air from an anatomical cavity in a surgical operation which allows the aforementioned technical drawbacks of the known art to be eliminated. Within the scope of this technical task, one aim of the invention is to provide a device that extremely effectively prevents the introduction of atmospheric air into the operating field during a surgical operation on an open organ. Another purpose of the invention is to realize a device that, after the closure of the organ and before its reintegration into the blood circulation, allows the complete removal of the air that has nevertheless managed to enter the organ.
    [0019] Another aim of the invention is to provide a device that removes air in a minimally cumbersome manner and without disturbing the surgical field.
    [0020] The technical task, as well as these and other purposes, according to the present invention are achieved by realizing a device for removing air from an anatomical cavity in a surgical intervention, characterized in that it comprises a flexible catheter with one or more lumens presenting a proximal end and a distal end, each lumen presenting one or more holes at an end portion of the catheter comprising the distal end, air suction means being also provided from the anatomical cavity, blowing means in the anatomical cavity of a gas of replacing air having a higher density of air, and lifting means of said terminal portion of the catheter for its placement at the top of the anatomical cavity, said insufflation means and said suction means being connected to the proximal end of the catheter. Advantageously, the device allows simultaneously to remove the air continuously during the surgery and replace it with a replacement gas that is not harmful to the patient.
    [0021] In the preferred application of cardiac surgery, the catheter is introduced through the aorta so as not to disturb the surgical field.
    [0022] In a preferred embodiment of the invention the catheter comprises a first lumen for introducing the substitution gas into the anatomical cavity in mechanical and fluid connection with the insufflation means and a second lumen for aspiration of air from the anatomical cavity in connection mechanical and fluidic with the air suction means.
    [0023] In a preferred embodiment of the invention the insufflation means are configured to supply a continuous flow of substitution gas in the first lumen.
    [0024] In a preferred embodiment of the invention the suction means are configured to generate a depression which extracts a continuous flow of air from the second lumen.
    [0025] In one embodiment of the invention the lifting means comprise a support wire which can be inserted into one of the lumens of said catheter.
    [0026] In one embodiment of the invention, said support wire is made of elastic material with a shape memory.
    [0027] In one embodiment of the invention, said support wire in release condition has two rectilinear portions joined by a bending point which orientates said two rectilinear portions transversely to one another.
    [0028] In another embodiment of the invention the lifting means are of the magnetic type.
    [0029] In another embodiment of the invention the lifting means are of the aerostatic type.
    [0030] In a preferred embodiment of the invention the catheter has means for deflecting the flow from the first to the second lumen. In a preferred embodiment of the invention the second lumen has a sensor of said replacement gas.
    [0031] In a preferred embodiment of the invention the air suction means and the insufflation means are connected to the same lumen of the catheter and can be activated selectively in an intermittent manner.
    [0032] Further characteristics and advantages of the invention will become more evident from the description of preferred but not exclusive embodiments of the device for removing air from an anatomical cavity in a surgical intervention according to the invention, illustrated only by way of non-limitative example in the attached drawings, in which: fig. 1 shows a first embodiment of the device for venting the left ventricle in a mini-invasive intervention of repair of the mitral valve in right thoracotomy; Fig. 2 shows the insertion of the catheter by guide wire; fig. 3a shows the catheter positioned in the left ventricle passing through the aorta; fig. 3b shows the catheter positioned in the left ventricle passing through the left atrium; fig. 4 shows the magnetic-type lifting means of the catheter; fig. 5 shows a cross-section of the catheter at the lifting means; fig. 6 shows an end portion of a catheter equipped with pneumatic-type lifting means, in a device according to a second preferred embodiment of the invention; fig. 7 shows a cross section of the catheter of fig. 6; fig. 8 shows the catheter of fig. 6 positioned in the left ventricle; fig. 9 shows another way of making the venting device in which the lifting means comprise a shape memory support wire.
    [0033] Equivalent parts in the following description will be indicated with the same numerical reference.
    [0034] With reference to the aforementioned figures, a device for removing air from an anatomical cavity in a surgical operation is shown, indicated as a whole with the reference number 1.
    [0035] In the following we will refer to a venting device in which the anatomical cavity is defined by the left ventricle 6 of the heart, although the scope of use of the device 1 according to the invention extends to other hollow anatomical organs including blood vessels . In the figure, in addition to the left ventricle 6, the left atrium 27 and the aorta 28 are also highlighted.
    [0036] The device 1 comprises a flexible catheter 2 with one or more lumens 10, 11 having a proximal end 3 and a distal end 4.
    [0037] At an end portion 9 of the catheter 2 comprising the distal end 4, each lumen 10, 11 has one or more through holes 12, 13.
    [0038] The through holes 12, 13 preferably involve an end portion of the catheter 2 of about 5 cm.
    [0039] The holes 12, 13 can be circular or ovoid or of another shape, their width at the maximum diameter is about 0.2 mm.
    [0040] The device 1 also comprises means 5 for sucking air from the anatomical cavity, means 7 for blowing into the anatomical cavity of an air-replacing gas having a higher air density, and means 8 for lifting the terminal portion 9 of the catheter 2 for its placement at the top of the anatomical cavity 6.
    [0041] The substitution gas is advantageously C02.
    [0042] Both the blowing means 7 and the suction means 5 are connected to the proximal end 3 of the catheter.
    [0043] More precisely, the catheter 2 comprises a first lumen 10 for introducing the substitution gas into the anatomical cavity 6, in mechanical and fluid connection with the insufflation means 7, and a second lumen 11 for aspiration of air from the anatomical cavity 6, in mechanical and fluid connection with the air suction means 5.
    [0044] The first lumen 10 is constituted by a flexible tube along which the holes 12 follow, which may also have different diameters to make the insufflated flow more uniform.
    [0045] The first lumen 10 also has its proximal end connected for example by means of a Luer connector 15 to an insufflation tube 17 which forms part of the blowing means 7.
    [0046] The second lumen 11 consists of a flexible tube along which the holes 13 follow, which may also have different diameters to make the aspirated flow more uniform.
    [0047] The second lumen 11 also has its proximal end connected for example by means of a Luer connector 16 to a suction tube 18 which is part of the suction means 5.
    [0048] The two lumens 10 and 11 are mechanically connected one parallel to the other and the holes 12 of one are offset with respect to the holes 13 of the other in the longitudinal direction of the catheter 2.
    [0049] Preferably at least the holes 13 of the suction lumen 11 follow one another along a path misaligned by the longitudinal axis of the catheter 2 to prevent the catheter 2 from being aspirated against the wall of the anatomical cavity.
    [0050] The two lumens 10, 11 may differ from each other in shape and / or size and / or wall thickness, their cross-section may be circular or ovoid or in any case such as to give the catheter 2 a different width and height so that it can be rigid in the direction of height and flexible in the direction of width or vice versa.
    [0051] The second lumen 11 has the distal end 26 open while the first lumen 10 has the distal end 25 closed and set back with respect to the distal end of the second lumen 11.
    [0052] The opening of at least one of the two lumens 10, 11 is necessary for the introduction of a guide wire 14 which provides for the in situ positioning of the catheter 2.
    [0053] Obviously both the distal ends of the two lumens 10, 11 may be open, for example in the embodiment of fig. 9. Catheter 2 is made of a material such as polyurethane or silicone or PEBAX or other commonly used, and its distal end 4 must in any case be made of soft material enough to avoid damaging the anatomical structures through which it is passed.
    [0054] The insufflation means 7 are configured to supply a continuous flow of substitution gas in the first lumen 10.
    [0055] The blowing-in means 7 can therefore comprise a source of replacement gas connected to a feed pump to whose delivery is in turn connected the blowing pipe 17, or a tank of pressurized replacement gas to whose delivery it is to in turn connected the insufflation tube 17.
    [0056] The suction means 5, on the other hand, are configured to generate a depression which draws a continuous flow of air from the second lumen 11.
    [0057] The suction means 5 can therefore comprise a vacuum pump to which the suction pipe 18 is in turn connected.
    [0058] The lifting means 8 can be of various types.
    [0059] In fig. 9, in the preferred solution, the lifting means 8 comprise a support wire 100 which can be inserted in one of the lumens of the catheter 2, in particular in one of the lumens 10, 11 or in another lumen specially provided for this purpose.
    [0060] The support wire 100 is made of elastic material with a shape memory. The support wire 100 in the condition of release has two substantially straight sections 100a, 100b joined by a bending point 100c which orientates the two rectilinear portions 100a, 100b transversely to one another.
    [0061] The support wire 100 can be made of a superelastic material such as a Nickel-Titanium alloy.
    [0062] Typically the support wire 100 has a circular cross-section of about 0.5 mm in diameter, but can have a cross-section of another shape and size.
    [0063] The support wire 100 can be preformed by heat treatment and subsequent quenching in such a way that at the room temperature in the released condition it presents the two rectilinear sections 100a, 100b joined by the bending point 100c which identifies an angle of about 90 °.
    [0064] The folding of the support wire 100 can be carried out in a plane (as shown) or even in different planes.
    [0065] The position of the folding point 100c and the bending angle of the support wire 100 can be varied according to requirements.
    [0066] The characteristics of the material are such that the bending point 100c can be straightened to insert it into the lumen of the catheter 2 without the support wire 100 being subjected to a plastic deformation.
    [0067] To facilitate straightening, the support wire 100 at the bending point 100c can have a different size and / or shape from its remaining part.
    [0068] The support wire 100 can present a special tip, for example rounded, at the distal end, to avoid damaging the biological tissue.
    [0069] Furthermore, the support wire 100 may have a marker element which indicates the bending direction and a marker element which indicates when the bending point 100c has emerged from the distal end of the catheter 2.
    [0070] Furthermore, the support wire 100 can present a handle at the proximal end to facilitate its insertion maneuver.
    [0071] The positioning of the catheter 2 at the top of the anatomical cavity takes place as follows. After the insertion of the catheter 2 into the anatomical cavity by sliding along a guide wire and removing the latter once the catheter 2 is in the anatomical cavity, the support wire 100 is inserted into a lumen of the catheter 2. The wire of support 100 must be straightened by hand or with a suitable tool to be able to advance along the lumen of the catheter 2. As long as the bending point 100c remains in the lumen of the catheter 2, the support wire 100 remains straightened due to the containment exerted by the wall of the lumen of the catheter 2. Then, as a result of the advancement of the support wire 100 along the lumen of the catheter 2, the bending point 100c protrudes from the distal end of the catheter 2, the support wire 100 resumes its natural shape since there is no longer the constriction of the lumen wall. In the absence of constraints on the bending point 100c, the section 100b is arranged in the anatomical cavity at an angle with respect to the section 100a which remains in the lumen of the catheter 2. In this situation the support wire 100 can be oriented by rotation on itself of the tract 100a in such a way that the distal end of the tract 100b points and pushes against the bottom of the anatomical cavity thus acting as a pivot which lifts and maintains the catheter 2 positioned at the top of the anatomical cavity.
    [0072] The lifting means 8 can alternatively be of the magnetic or aerostatic type.
    [0073] Example of magnetic lifting means 8 is a magnetic or ferromagnetic element 20, in particular an elastic spiral metal wire, mechanically connected to the terminal portion 9 of the catheter 2 and adapted to interact with a magnet 21, in particular an electromagnet or a permanent magnet, which can be placed in a suitable position above the operating field.
    [0074] Example of magnetic lifting means 8 is a magnetic or ferromagnetic element 20, in particular an elastic spiral metal wire, mechanically connected to the terminal portion 9 of the catheter 2 and adapted to interact with a magnet 21, in particular an electromagnet or a permanent magnet, which can be placed in a suitable position above the operating field.
    [0075] An example of aerostatic lifting means 8 is an inflatable balloon 22 with an inflation gas having a lower air density mechanically connected to the terminal portion 9 of the catheter 2. In this case the catheter 2 is provided with a further lumen 23 for supplying the inflation gas to the balloon 22, and the lumen for supplying the inflation gas in turn is in mechanical and fluidic connection with appropriate inflation means for inflating gases (not shown) which must be able to reverse their operation to allow also the deflating of the balloon when the catheter 2 has to be extracted. The inflation gas blowing means can comprise a reversible feed pump connected to an inflation gas source which is by way of example He. The balloon 22 is able to lift or at least assist the lifting of the catheter 2 ensuring its floating on the surface of the physiological solution or of the blood present in the anatomical cavity. The operation of device 1 with reference to the mitral valve repair application is briefly the following. This application will be described only as a non-limiting example with reference to lifting means 8 of the magnetic or aerostatic type, since the operation of the support wire 100 has already been described previously.
    [0076] The catheter 2 is inserted through the left atrium 28 or through the aorta 27. In the aorta 27 a dedicated puncture site can be identified for the introduction of the catheter 2 or the catheter 2 can be introduced through it puncture site from which the cardioplegia cannula was introduced.
    [0077] If the catheter 2 is inserted through the aorta 27 it can be pushed in retrograde motion towards the aortic valve through a standard technique with the guide wire 14 in which first the guide wire 14 is passed through the aortic valve and subsequently the catheter 2 is slid over it.
    [0078] After the catheter 2 reaches its position in the left ventricle 6 the guide wire 14 can be removed.
    权利要求:
    Claims (15)
    [1]
    [0079] At this point the lifting means 8 are activated to position and maintain positioned the terminal part 9 of the catheter 2 in correspondence with the sky of the left ventricle 6. Then in the case of the magnetic lifting means 8 the magnet 21 is brought into a the range of action which embraces the element 20, while in the case of the aerostatic lifting means 8 the balloon is inflated [0080] At this point the suction means 5 and the blowing means 7 are activated. [0081] The means of insufflation 7 creates a constant positive pressure over time and at the same time the suction means 5 create a constant negative pressure over time. [0082] The filling gas, being heavier than air, comes out of the holes 12 of the first lumen 10 and sinks towards the bottom of the left ventricle 6 filling it and replacing lighter air which is pushed towards the sky of the left ventricle 6 from which it is then sucked through the holes 13 of the second lumen 11 to finally be eliminated. [0083] The C02 gas which at the end of the residual intervention in the left ventricle 6 is harmless and dissolves in the blood. [0084] In this way the air is sucked from the left ventricle 6, however C02 and / or blood can also be aspirated in the absence of air. [0085] Advantageously, deviation means (not shown) may be provided to intervene to interrupt the fluid connection between the suction means 5 and the second lumen 11 and establish a fluid connection between the blowing means 7 and the second lumen 11.1 means of deviation they intervene if and when there is the need to unclog the second lumen 11. In fact it can happen that the second lumen 11 is aspirated against the wall of the anatomical cavity or that blood has been aspirated. The temporary inversion of the gas flow in the second lumen 11 determines in this case the complete unblocking of the second lumen 11 itself. The diverting means can for example comprise a three-way valve. The diverting means can also be automated to intervene whenever the suction pressure or the flow of air sucked into the second lumen 11 goes below a certain threshold value. [0086] Advantageously, the device can be used at the end of the mitral valve repair operation to perform a test on the functionality of the mitral valve itself, which consists in rapidly filling the ventricle with a quantity of saline saline solution such as to pressurize the ventricle and induce the closure of the mitral valve. [0087] The device thus conceived is susceptible of numerous modifications and variations, all of which are within the scope of the inventive concept; furthermore all the details may be replaced by technically equivalent elements. [0088] For example, means for adjusting the temperature of the replacement gas and / or of the inflation gas can be provided which can be heated or cooled in a tolerable temperature range for the patient to optimize the effect obtained by the differentiation of the their density. [0089] Furthermore, the second lumen 11 may be equipped with a sensor (not shown) for the replacement gas, based for example on the infrared light diffraction or on the transmission with the function of temporarily interrupting or reducing the operating mode of the suction means 5 when the replacement gas sensor detects C02 in the single flow without air. [0090] Finally, a simplified version of the device according to the invention provides that the air suction means 5 and the blowing means 7 are connected to the same lumen of the catheter 2 and can be activated selectively in an intermittent manner. In practice, an automated valve system switches to selectively and alternately connect the blowing means 7 and the suction means 5 to the same lumen of the catheter 2. In this case an alternating sequence of insufflations of filling gases and aspirations of air from the cavity anatomical. claims
    1. Device (1) for removing air from an anatomical cavity (6) in a surgical intervention, characterized in that it comprises a flexible catheter (2) with one or more lumens (10, 11) having a proximal end (3 ) and a distal end (4), each lumen (10, 11) presenting one or more holes (12, 13) in correspondence with an end portion (9) of the catheter (2) comprising the distal end (4), being furthermore, means (5) for sucking air from the anatomical cavity (6), means (7) for blowing into the anatomical cavity (6) of an air replacement gas having a higher air density, and means (8) raising of said terminal portion (9) of the catheter (2) due to its placement at the top of the anatomical cavity (6), said insufflation means (7) and said suction means (5) being connected to the proximal end (3) of the catheter (2).
    [2]
    2. Device (1) for removing air from an anatomical cavity according to the previous claim, characterized in that said catheter (2) comprises a first lumen (10) for introducing the replacement gas into the anatomical cavity (6) in connection mechanical and fluidic with the blowing means (7) and a second lumen (11) for sucking air from the anatomical cavity (6) in mechanical and fluid connection with the suction means (5).
    [3]
    3. Device (1) for removing air from an anatomical cavity according to the previous claim, characterized in that said insufflation means (7) are configured to supply a continuous flow of substitution gas in the first lumen (10).
    [4]
    4. Device (1) for removing air from an anatomical cavity according to any one of the claims 2 and 3, characterized in that said suction means (5) are configured to generate a depression which extracts a continuous flow of air from the second lumen (11).
    [5]
    5. Device (1) for removing air from an anatomical cavity according to any claim from 2 to 4, characterized in that said first and second lumens (10, 11) are mechanically connected one parallel to the other.
    [6]
    6. Device (1) for removing air from an anatomical cavity according to any previous claim, characterized in that said substitution gas is C02.
    [7]
    7. Device (1) for removing air from an anatomical cavity according to any previous claim, characterized in that said lifting means (8) comprise a support wire that can be inserted into one of the lumens of said catheter (2).
    [8]
    8. Device (1) for removing air from an anatomical cavity according to the previous claim, characterized in that said support wire is made of elastic material with a shape memory.
    [9]
    9. Device (1) for removing air from an anatomical cavity according to the previous claim, characterized in that said support wire in release condition has two rectilinear portions joined by a bending point which orientates said two rectilinear transverse sections l 'one to the other.
    [10]
    10. Device (1) for removing air from an anatomical cavity according to any of the claims from 1 to 6, characterized in that said lifting means (8) are magnetic.
    [11]
    11. Device (1) for removing air from an anatomical cavity according to any claim from 1 to 6, characterized in that said lifting means (8) are aerostatic.
    [12]
    12. Device (1) for removing air from an anatomical cavity according to any previous claim, characterized in that it has means for adjusting the temperature of the replacement gas.
    [13]
    13. Device (1) for removing air from an anatomical cavity according to any claim from 2 to 12, characterized in that said catheter (2) has means for deviating the flow from the first moun (10) to the second lumen (11 ) for the unblocking of the latter.
    [14]
    14. Device (1) for removing air from an anatomical cavity according to any claim from 2 to 13, characterized in that said second lumen (11) has a sensor of said replacement gas.
    [15]
    15. Device (1) for removing air from an anatomical cavity according to claim 1, characterized in that said air suction means (5) and said insufflation means (7) are connected to a same lumen of the catheter and they can be activated intermittently selectively.
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    同族专利:
    公开号 | 公开日
    EP3386579A1|2018-10-17|
    CN108367135A|2018-08-03|
    JP2019503739A|2019-02-14|
    CA3007760A1|2017-06-15|
    CH711858B1|2019-10-31|
    AU2016368371A1|2018-06-28|
    BR112018011650A2|2018-12-04|
    KR20180091890A|2018-08-16|
    WO2017097443A1|2017-06-15|
    US20180361115A1|2018-12-20|
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    法律状态:
    2018-06-15| NV| New agent|Representative=s name: RAPISARDI INTELLECTUAL PROPERTY SA, CH |
    2018-06-15| PUE| Assignment|Owner name: LUGANO TECHNOLOGY TRANSFER (LTT) SA, CH Free format text: FORMER OWNER: FONDAZIONE CARDIOCENTRO TICINO (FCCT), CH |
    2020-11-30| PUE| Assignment|Owner name: FOUNDATION FOR CARDIOLOGICAL RESEARCH AND EDUC, CH Free format text: FORMER OWNER: LUGANO TECHNOLOGY TRANSFER (LTT) SA, CH |
    优先权:
    申请号 | 申请日 | 专利标题
    CH17922015A|CH711858B1|2015-12-09|2015-12-09|Device for removing air from an anatomical cavity in a surgical procedure.|
    ITUB2015A006844A|ITUB20156844A1|2015-12-09|2015-12-09|DEVICE FOR AIR REMOVAL FROM ANATOMIC CAVITY IN A SURGICAL INTERVENTION|CH17922015A| CH711858B1|2015-12-09|2015-12-09|Device for removing air from an anatomical cavity in a surgical procedure.|
    EP16745676.3A| EP3386579A1|2015-12-09|2016-07-25|Device for removing air from an anatomical cavity in a surgical intervention|
    JP2018530765A| JP2019503739A|2015-12-09|2016-07-25|Device for removing air from anatomic cavities during surgical intervention|
    CN201680072306.5A| CN108367135A|2015-12-09|2016-07-25|Device for removing air from anatomical cavity in surgical intervention|
    CA3007760A| CA3007760A1|2015-12-09|2016-07-25|Device for removing air from an anatomical cavity in a surgical intervention|
    BR112018011650A| BR112018011650A2|2015-12-09|2016-07-25|device for removal of air from an anatomical cavity in a surgical intervention|
    PCT/EP2016/067626| WO2017097443A1|2015-12-09|2016-07-25|Device for removing air from an anatomical cavity in a surgical intervention|
    US16/060,679| US20180361115A1|2015-12-09|2016-07-25|Device for removing air from an anatomical cavity in a surgical intervention|
    AU2016368371A| AU2016368371A1|2015-12-09|2016-07-25|Device for removing air from an anatomical cavity in a surgical intervention|
    KR1020187019451A| KR20180091890A|2015-12-09|2016-07-25|Devices for removing air from anatomical cavities in surgical intervention|
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